Newcastle held on to beat Southampton despite finishing with nine men with Miguel Almiron scoring twice for the hosts at a rain-soaked St James’ Park.
The result sees Newcastle remain in 16th but may ease some of the pressure on manager Steve Bruce, whose side are now 11 points clear of the bottom three.
However, it was a dismal conclusion to the week for Southampton, who were unable to bounce back from their 9-0 defeat at Manchester United despite Jeff Hendrick’s dismissal early in the second half and an injury to Fabian Schar – when the hosts had already made their three substitutions.
On-loan Arsenal midfielder Joe Willock had given Newcastle a perfect start, steering in Allan Saint-Maximin’s cut-back to open the scoring on his debut before Almiron doubled their lead with a shot that deflected off Saints defender Jan Bednarek.
The Paraguay winger then restored Newcastle’s two-goal advantage after Takumi Minamino lashed in a brilliant debut goal for the Saints.
James Ward-Prowse’s wonderful free-kick had given Saints hope of rescuing a point even before Hendrick was sent off for two bookings, but a resilient Newcastle held on.
Southampton have now lost fifth consecutive top-flight games for the first time since September 1998.